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If Isaac runs out of both Red and Soul Hearts he will die and view his Last Will unless he has Dead Cat Ankh or 1UP. In order for Isaac to pick up Red Hearts he must have Heart Containers that can be gained from a number.
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If Isaac enters a room with a half Red Heart or less a pool of urine blood in Eves case will be formed under him.
. Every Treasure Room is replaced with a Devil Treasure Room that contain items from the Devil Room item pool that can be bought for the usual number of Heart Containers normally requested for the spawned item in a Devil Room. The Angel Room can replace the Devil Room on any floor. Devils Crown is an unlockable trinket added in The Binding of Isaac.
Angel Room is a special room that was added in the Wrath of the Lamb DLC. In Rebirth the statue can be destroyed by a bomb and an Angel will appear which needs to be fought. The Devil Treasure Room generated will be the same as the Treasure.
However instead of Satan sitting there an angel has taken his place. Hearts are Pick Ups that replenish Isaacs health. Like the Devil Room it presents a simple offering.
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